Negative regulation of T cell proliferation

Across TCGA patient cohorts, RNA activity of the Negative regulation of T cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, SAMSN1, and SAMSN1_S107, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of T cell proliferation activity versus RCSD1 in LSCC (Pearson r = 0.73).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RCSD1 →	+0.655	+0.098	<.001	<.001	3	10
GBM	SAMSN1 →	+0.588	+0.056	<.001	<.001	3	10
BRCA	SAMSN1_S107 →	+0.867	+0.045	<.001	<.001	3	10
LSCC	SAMSN1_S23 →	+0.933	+0.099	<.001	<.001	3	10
LSCC	SASH3 →	+0.555	+0.104	<.001	<.001	3	10
GBM	SKAP2 →	+0.856	+0.081	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042130 vs RCSD1 — LSCC

Explore this scatter interactively →