Negative regulation of T cell proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of T cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C3orf35, MRPL37, and SDHB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C3orf35 grouped by Negative regulation of T cell proliferation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	C3orf35 →	+0.205	+1.035	.001	<.001	3	4
BONE	MRPL37 →	-0.656	-1.470	.003	.004	3	3
UPPER_AERODIGESTIVE_TRACT	SDHB →	-0.746	-1.545	.003	<.001	3	3
BONE	LONRF2 →	+0.775	+1.822	.001	<.001	3	3
BONE	CCDC85B →	+0.859	+1.699	<.001	<.001	3	3
PANCREAS	FEM1C →	+0.735	+0.929	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C3orf35 by Negative regulation of T cell proliferation activity — OVARY

Explore this box plot interactively →