Negative regulation of T cell proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of T cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FRAT2, TLN1, and FYN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of T cell proliferation activity versus FRAT2 in BREAST (Pearson r = -0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FRAT2 →	-1.351	-0.627	<.001	.002	3	6
BLOOD_Lymphoma	TLN1 →	+0.701	+0.527	<.001	.009	3	5
BREAST	FYN →	+2.558	+0.481	<.001	.004	2	6
SKIN	STK32A →	+2.243	+0.276	.002	.002	3	4
OVARY	DCBLD2 →	+2.367	+1.227	.003	.005	3	4
BREAST	PEX11A →	-1.670	-0.820	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042130 vs FRAT2 — BREAST

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