Endothelial cell activation

Across TCGA cell cohorts, RNA activity of the Endothelial cell activation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL12, RUFY2, and MTAP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPL12 grouped by Endothelial cell activation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RPL12 →	+0.501	+0.482	.001	.002	3	4
LARGE_INTESTINE	RUFY2 →	-0.587	-0.722	.002	.002	3	4
LIVER	MTAP →	-2.776	-1.350	.008	.006	3	4
UPPER_AERODIGESTIVE_TRACT	LYPD5 →	+1.083	+1.141	.001	<.001	3	3
SKIN	RPL28 →	+0.540	+0.915	.009	.001	3	3
SKIN	ZNF354A →	-0.950	-1.106	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPL12 by Endothelial cell activation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →