Endothelial cell activation

Across TCGA cell cohorts, RNA activity of the Endothelial cell activation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are REEP6, BIRC3, and MEX3A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endothelial cell activation activity versus REEP6 in BREAST (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	REEP6 →	+2.145	+0.120	<.001	<.001	3	7
SKIN	BIRC3 →	+1.473	+0.097	.003	<.001	3	6
LIVER	MEX3A →	-2.460	-0.095	.007	.008	3	5
BREAST	UNC5A →	+1.407	+0.142	<.001	<.001	3	5
URINARY_TRACT	NME3 →	-2.210	-0.103	.005	.003	3	4
LUNG_NSCLC_LUSC	IL27RA →	+2.114	+0.157	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042118 vs REEP6 — BREAST

Explore this scatter interactively →