Monocyte activation

Across TCGA cell cohorts, RNA activity of the Monocyte activation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are U2AF1L4, AZGP1, and SDCBP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, U2AF1L4 grouped by Monocyte activation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	U2AF1L4 →	+0.707	+1.199	.001	.007	3	4
PANCREAS	AZGP1 →	-2.685	-1.178	.001	.003	3	3
BREAST	SDCBP2 →	+1.872	+1.025	<.001	<.001	3	3
BREAST	PUS10 →	+0.717	+1.104	.002	<.001	3	3
BREAST	MRTFA →	+0.910	+0.983	<.001	.001	3	3
LARGE_INTESTINE	NAGPA →	+0.455	+1.054	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

U2AF1L4 by Monocyte activation activity — STOMACH

Explore this box plot interactively →