Monocyte activation

Across TCGA cell cohorts, RNA activity of the Monocyte activation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MET, MYOF, and ALDH1A3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monocyte activation activity versus MET in BONE (Pearson r = 0.89).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MET →	+4.520	+1.753	.002	<.001	2	5
STOMACH	MYOF →	+3.901	+0.441	.003	.002	3	4
STOMACH	ALDH1A3 →	+6.721	+0.478	<.001	<.001	3	4
SKIN	MILR1 →	+4.253	+1.559	<.001	<.001	3	4
BLOOD_Leukemia	HDAC9 →	+2.197	+1.281	<.001	<.001	3	4
OVARY	CRYBG1 →	+1.312	+0.250	.002	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042117 vs MET — BONE

Explore this scatter interactively →