Monocyte activation

Across TCGA cell cohorts, RNA activity of the Monocyte activation pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADAM10, ADAM9, and MCU, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monocyte activation activity versus ADAM10 in LUNG_SCLC (Pearson r = 0.77).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ADAM10 →	+1.664	+1.738	<.001	<.001	3	10
STOMACH	ADAM9 →	+1.985	+0.488	.002	<.001	3	10
BONE	MCU →	+1.698	+1.666	<.001	<.001	3	6
BLOOD_Leukemia	ERLIN1 →	+1.176	+0.861	.002	.003	2	6
STOMACH	ESYT2 →	+1.067	+0.586	<.001	<.001	3	5
BONE	ANKH →	+2.228	+1.359	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042117 vs ADAM10 — LUNG_SCLC

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