Macrophage activation

Across TCGA patient cohorts, RNA activity of the Macrophage activation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LILRB2, PIK3R5, and LST1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Macrophage activation activity versus LILRB2 in GBM (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LILRB2 →	+0.660	+0.129	<.001	<.001	3	8
GBM	PIK3R5 →	+0.830	+0.169	<.001	<.001	3	8
HNSC	LST1 →	+0.976	+0.198	<.001	<.001	3	8
GBM	IFI30 →	+0.779	+0.148	<.001	<.001	3	8
UCEC	MIR223HG →	+1.015	+0.265	<.001	<.001	3	8
GBM	TBXAS1 →	+0.693	+0.127	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042116 vs LILRB2 — GBM

Explore this scatter interactively →