Macrophage activation

Across TCGA cell cohorts, RNA activity of the Macrophage activation pathway is significantly associated with the protein abundance of multiple proteins, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FUS, SUB1, and PCNA, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Macrophage activation activity versus FUS in BONE (Pearson r = 0.60).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	FUS →	+1.058	+0.920	.003	.002	3	7
LARGE_INTESTINE	SUB1 →	+1.309	+0.824	.002	<.001	3	6
LARGE_INTESTINE	PCNA →	+1.530	+0.836	.001	.007	3	6
LUNG_NSCLC_LUAD	PML →	-1.427	-0.803	<.001	.001	3	6
LARGE_INTESTINE	PI4K2A →	-1.190	-0.840	<.001	<.001	3	6
SOFT_TISSUE	MARCKSL1 →	+2.359	+1.209	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042116 vs FUS — BONE

Explore this scatter interactively →