B cell activation

Across TCGA cell cohorts, RNA activity of the B cell activation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SERPINA1, EVI2B, and EGLN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SERPINA1 grouped by B cell activation-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SERPINA1 →	+0.328	+0.208	<.001	<.001	3	5
BLOOD_Leukemia	EVI2B →	+2.330	+0.169	.002	.009	3	5
BLOOD_Leukemia	EGLN1 →	+1.066	+0.137	.006	.008	3	4
LUNG_NSCLC_LUSC	SLC41A2 →	+1.993	+0.212	<.001	<.001	3	4
KIDNEY	OAZ3 →	+0.623	+0.182	.001	<.001	3	4
STOMACH	SH3BP1 →	-1.298	-0.145	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SERPINA1 by B cell activation activity — BLOOD_Myeloma

Explore this box plot interactively →