B cell activation

Across TCGA cell cohorts, RNA activity of the B cell activation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM210A, PLGLB1, and PHLDA2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, B cell activation activity versus FAM210A in BONE (Pearson r = -0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	FAM210A →	-1.557	-0.219	.008	.002	3	5
LIVER	PLGLB1 →	+0.875	+0.169	<.001	.002	3	4
BONE	PHLDA2 →	-4.516	-0.257	.003	.001	3	4
STOMACH	CEP19 →	+1.182	+0.231	.007	.004	2	5
BLOOD_Leukemia	CTTN →	-1.573	-0.078	.001	.006	3	4
SOFT_TISSUE	ACAA2 →	+1.933	+0.244	.008	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042113 vs FAM210A — BONE

Explore this scatter interactively →