Positive regulation of activated T cell proliferation

Across TCGA patient cohorts, RNA activity of the Positive regulation of activated T cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGFBP2, ATP7B, and KIF1A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of activated T cell proliferation activity versus IGFBP2 in BRCA (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IGFBP2 →	+1.059	+0.138	<.001	<.001	3	4
BRCA	ATP7B →	+0.836	+0.141	<.001	.002	3	4
GBM	KIF1A →	+0.740	+0.111	.007	.008	3	4
BRCA	TMEM25 →	+0.821	+0.174	.002	<.001	3	4
HNSC	CD1B →	-1.084	-0.113	<.001	.001	3	4
BRCA	DNAJC12 →	+1.519	+0.111	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042104 vs IGFBP2 — BRCA

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