Positive regulation of activated T cell proliferation

Across TCGA patient cohorts, RNA activity of the Positive regulation of activated T cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IGFBP2, RPL18A, and PEA15_S90, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of activated T cell proliferation activity versus IGFBP2 in LUAD (Pearson r = 0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	IGFBP2 →	+0.920	+0.196	<.001	<.001	3	5
PDAC	RPL18A →	-0.442	-0.097	<.001	<.001	3	4
GBM	PEA15_S90 →	+0.474	+0.160	<.001	<.001	3	4
OV	SKP1_T131 →	+0.676	+0.166	<.001	<.001	3	4
GBM	USP43_S625 →	+0.824	+0.205	<.001	<.001	3	3
OV	HSPB1_S176 →	-1.135	-0.251	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042104 vs IGFBP2 — LUAD

Explore this scatter interactively →