Positive regulation of activated T cell proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of activated T cell proliferation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPA3, VIP, and IGF2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPA3 grouped by Positive regulation of activated T cell proliferation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RPA3 →	+0.212	+0.188	.003	.004	3	3
LARGE_INTESTINE	VIP →	-0.135	-0.314	.001	<.001	3	3
LARGE_INTESTINE	IGF2 →	-0.243	-0.429	.003	<.001	3	3
SKIN	ADAM32 →	+0.182	+0.167	.003	.004	3	3
PANCREAS	COL7A1 →	+0.247	+0.246	.009	.005	3	3
PANCREAS	GRID2 →	+0.257	+0.307	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPA3 by Positive regulation of activated T cell proliferation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →