Positive regulation of T cell proliferation

Across TCGA patient cohorts, RNA activity of the Positive regulation of T cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, RCSD1_S179, and RCSD1_S351, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T cell proliferation activity versus RCSD1 in HNSC (Pearson r = 0.59).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RCSD1 →	+0.658	+0.090	<.001	<.001	3	10
LSCC	RCSD1_S179 →	+0.827	+0.105	<.001	<.001	3	10
OV	RCSD1_S351 →	+0.691	+0.041	.001	<.001	3	10
UCEC	RGS19 →	+0.702	+0.070	<.001	.005	3	10
BRCA	SAMSN1_S23 →	+0.990	+0.057	<.001	<.001	3	10
GBM	SASH3 →	+0.566	+0.095	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042102 vs RCSD1 — HNSC

Explore this scatter interactively →