Positive regulation of T cell proliferation

Across TCGA patient cohorts, RNA activity of the Positive regulation of T cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYTH4, APOBEC3H, and GRAP2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T cell proliferation activity versus CYTH4 in GBM (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CYTH4 →	+0.797	+0.241	<.001	<.001	3	10
OV	APOBEC3H →	+0.821	+0.274	<.001	<.001	3	10
LSCC	GRAP2 →	+0.687	+0.298	<.001	<.001	3	10
HNSC	CSF2RB →	+1.093	+0.335	<.001	<.001	3	10
OV	IL2RB →	+1.279	+0.313	<.001	<.001	3	10
OV	TLR8 →	+0.959	+0.258	.002	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042102 vs CYTH4 — GBM

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