Positive regulation of T cell proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of T cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMPD2, INHBA, and TMC4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SMPD2 grouped by Positive regulation of T cell proliferation-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SMPD2 →	+0.829	+0.927	.004	.001	3	5
UPPER_AERODIGESTIVE_TRACT	INHBA →	-2.466	-1.041	<.001	.007	3	5
LUNG_NSCLC_LUSC	TMC4 →	+1.755	+1.112	<.001	.004	3	4
SOFT_TISSUE	HECW2 →	-1.988	-1.083	.003	.005	3	4
BLOOD_Leukemia	APLF →	-0.579	-1.251	.004	.001	3	3
BLOOD_Leukemia	NFKBIL1 →	-0.906	-1.059	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SMPD2 by Positive regulation of T cell proliferation activity — PANCREAS

Explore this box plot interactively →