Positive regulation of T cell proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of T cell proliferation pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB24, MAP3K15, and RAD54L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB24 grouped by Positive regulation of T cell proliferation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RAB24 →	-0.099	-0.173	.002	.001	3	4
BLOOD_Leukemia	MAP3K15 →	+0.210	+0.247	<.001	.002	3	4
LIVER	RAD54L →	-0.230	-0.377	.002	<.001	3	4
BREAST	SFR1 →	+0.109	+0.219	.005	.004	3	4
LUNG_NSCLC_LUSC	AARD →	+0.196	+0.199	.008	.002	3	4
SKIN	PROM2 →	+0.306	+0.245	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB24 by Positive regulation of T cell proliferation activity — SKIN

Explore this box plot interactively →