Positive regulation of T cell proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of T cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMPRSS13, PTPN12, and JMJD4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T cell proliferation activity versus TMPRSS13 in SOFT_TISSUE (Pearson r = -0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TMPRSS13 →	-0.040	-0.307	<.001	.002	3	6
LARGE_INTESTINE	PTPN12 →	+0.745	+0.220	<.001	<.001	3	6
BLOOD_Myeloma	JMJD4 →	-1.070	-0.377	.002	.004	3	6
BREAST	JPH1 →	-1.503	-0.241	.001	<.001	3	6
BREAST	BIRC2 →	+1.082	+0.255	<.001	<.001	3	5
BREAST	UBLCP1 →	+0.876	+0.251	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042102 vs TMPRSS13 — SOFT_TISSUE

Explore this scatter interactively →