B cell proliferation

Across TCGA patient cohorts, RNA activity of the B cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EBI3, DOCK2, and FGD2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, B cell proliferation activity versus EBI3 in HNSC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	EBI3 →	+1.098	+1.055	<.001	<.001	3	8
HNSC	DOCK2 →	+0.951	+0.959	<.001	<.001	3	7
LSCC	FGD2 →	+0.693	+0.523	<.001	<.001	3	7
LSCC	MEI1 →	+0.742	+0.404	<.001	<.001	3	7
LSCC	POU2F2 →	+0.967	+0.561	<.001	<.001	3	7
HNSC	SP140 →	+1.102	+0.956	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042100 vs EBI3 — HNSC

Explore this scatter interactively →