B cell proliferation

Across TCGA cell cohorts, RNA activity of the B cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CUTC, INSIG2, and SLC23A2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CUTC grouped by B cell proliferation-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CUTC →	+1.070	+0.571	.002	.006	3	3
BLOOD_Lymphoma	INSIG2 →	-0.590	-0.447	.001	.008	3	3
BLOOD_Lymphoma	SLC23A2 →	+1.797	+0.587	.003	.003	3	3
STOMACH	WRAP53 →	+0.634	+1.056	<.001	.001	3	3
STOMACH	BUB3 →	+0.668	+1.015	.009	.006	3	3
OVARY	EIF4A1 →	+0.708	+1.029	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CUTC by B cell proliferation activity — BLOOD_Lymphoma

Explore this box plot interactively →