B cell proliferation

Across TCGA cell cohorts, RNA activity of the B cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PGD, PERM1, and PEX12, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, B cell proliferation activity versus PGD in STOMACH (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PGD →	+1.017	+0.227	.007	.009	3	4
STOMACH	PERM1 →	-1.121	-0.213	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	PEX12 →	+0.717	+0.247	.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	CZIB →	+0.841	+0.211	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	NUDT13 →	+0.986	+0.258	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	PPIE →	+0.637	+0.188	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042100 vs PGD — STOMACH

Explore this scatter interactively →