T cell proliferation

Across TCGA patient cohorts, RNA activity of the T cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLR8, LILRB1, and CD33, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell proliferation activity versus TLR8 in OV (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TLR8 →	+1.373	+0.248	<.001	<.001	3	3
OV	LILRB1 →	+1.324	+0.232	<.001	<.001	3	3
OV	CD33 →	+1.067	+0.269	<.001	<.001	3	3
BRCA	PIK3CG →	+0.779	+0.251	.004	.001	3	3
OV	TFEC →	+1.336	+0.231	.001	<.001	3	3
BRCA	P2RX1 →	+1.360	+0.378	.003	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042098 vs TLR8 — OV

Explore this scatter interactively →