T cell proliferation

Across TCGA cell cohorts, RNA activity of the T cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BTN3A3, BTN3A1, and GBP1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell proliferation activity versus BTN3A3 in LUNG_NSCLC_LUSC (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	BTN3A3 →	+1.703	+0.176	.001	<.001	3	10
CNS	BTN3A1 →	+1.190	+0.113	<.001	<.001	3	10
BONE	GBP1 →	+2.647	+0.158	.001	<.001	3	8
BONE	CDK17 →	+0.894	+0.130	.002	.002	3	8
OVARY	CD70 →	+2.936	+0.113	<.001	.001	3	7
LUNG_NSCLC_LUAD	COL6A2 →	+3.102	+0.116	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042098 vs BTN3A3 — LUNG_NSCLC_LUSC

Explore this scatter interactively →