T cell proliferation

Across TCGA cell cohorts, RNA activity of the T cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPL, SRRM3, and EEF2K, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell proliferation activity versus PPL in LUNG_NSCLC_LUAD (Pearson r = -0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PPL →	-1.973	-0.266	<.001	.002	3	5
UPPER_AERODIGESTIVE_TRACT	SRRM3 →	+1.748	+0.575	<.001	<.001	3	4
BLOOD_Lymphoma	EEF2K →	+0.849	+0.169	.003	.009	3	4
SOFT_TISSUE	B3GAT3 →	+0.853	+0.240	.002	<.001	3	4
BLOOD_Myeloma	TEX38 →	+0.152	+0.158	.001	.008	3	4
LUNG_NSCLC_LUAD	AAAS →	+0.754	+0.409	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042098 vs PPL — LUNG_NSCLC_LUAD

Explore this scatter interactively →