Type 2 immune response

Across TCGA patient cohorts, RNA activity of the Type 2 immune response pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DIPK1A, EXTL2, and CALHM5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Type 2 immune response activity versus DIPK1A in BRCA (Pearson r = -0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DIPK1A →	-0.696	-0.697	.003	<.001	3	4
BRCA	EXTL2 →	-0.492	-0.491	.001	.002	3	4
HNSC	CALHM5 →	-0.737	-0.535	<.001	<.001	3	4
HNSC	INHBA →	-0.787	-0.344	.008	.007	3	4
LSCC	CDH11 →	-0.590	-0.503	.006	.005	3	4
LUAD	HCFC1R1 →	-0.361	-0.400	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042092 vs DIPK1A — BRCA

Explore this scatter interactively →