Type 2 immune response

Across TCGA cell cohorts, RNA activity of the Type 2 immune response pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABCC11, RPL35, and DNAJC12, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ABCC11 grouped by Type 2 immune response-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ABCC11 →	+2.203	+0.622	.004	.005	3	4
OESOPHAGUS	RPL35 →	+0.431	+1.149	.005	<.001	3	4
OVARY	DNAJC12 →	+1.103	+0.751	.004	.007	3	4
LUNG_NSCLC_LUAD	TICAM2 →	+0.932	+0.994	<.001	<.001	3	4
BONE	MAP2K4 →	-0.665	-1.111	.006	.001	3	3
SOFT_TISSUE	ATRNL1 →	+1.577	+1.400	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ABCC11 by Type 2 immune response activity — BREAST

Explore this box plot interactively →