Type 2 immune response

Across TCGA cell cohorts, RNA activity of the Type 2 immune response pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NME4, NDUFA5, and CREBBP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NME4 grouped by Type 2 immune response-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	NME4 →	+0.158	+1.510	.002	.001	3	3
OVARY	NDUFA5 →	-0.148	-1.332	.005	.006	3	3
STOMACH	CREBBP →	+0.300	+1.805	.004	.001	2	4
PANCREAS	HBD →	+0.126	+1.045	.001	.002	3	3
LUNG_NSCLC_LUAD	CDK20 →	+0.205	+1.774	.001	<.001	3	2
OVARY	CHEK1 →	+0.507	+1.851	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NME4 by Type 2 immune response activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →