Type 2 immune response

Across TCGA cell cohorts, RNA activity of the Type 2 immune response pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOXO3, PDGFB, and IL18, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Type 2 immune response activity versus FOXO3 in LUNG_NSCLC_LUAD (Pearson r = -0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	FOXO3 →	-1.263	-1.540	<.001	<.001	3	4
OVARY	PDGFB →	-2.358	-1.464	.005	.002	2	4
OVARY	IL18 →	+1.871	+1.557	.004	<.001	3	3
LARGE_INTESTINE	KSR2 →	+0.455	+1.022	<.001	<.001	3	3
LARGE_INTESTINE	RUBCN →	+0.686	+0.943	.001	.002	3	3
LARGE_INTESTINE	MUCL3 →	+0.146	+1.089	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042092 vs FOXO3 — LUNG_NSCLC_LUAD

Explore this scatter interactively →