T-helper 1 type immune response

Across TCGA patient cohorts, RNA activity of the T-helper 1 type immune response pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYO1F, CD2, and ARHGAP9, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T-helper 1 type immune response activity versus MYO1F in GBM (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MYO1F →	+1.069	+1.066	<.001	<.001	3	9
OV	CD2 →	+1.474	+0.736	<.001	.005	3	8
GBM	ARHGAP9 →	+1.068	+1.390	<.001	<.001	3	8
BRCA	CD96 →	+0.950	+0.823	<.001	<.001	3	8
OV	NCF1 →	+0.716	+0.798	<.001	.001	3	8
CCRCC	ICOS →	+0.977	+0.681	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042088 vs MYO1F — GBM

Explore this scatter interactively →