T-helper 1 type immune response

Across TCGA cell cohorts, RNA activity of the T-helper 1 type immune response pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMB9, PSMB8, and BTN3A3, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T-helper 1 type immune response activity versus PSMB9 in BREAST (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PSMB9 →	+2.478	+0.130	<.001	<.001	3	12
BREAST	PSMB8 →	+1.906	+0.119	<.001	<.001	3	11
BLOOD_Lymphoma	BTN3A3 →	+1.829	+0.095	<.001	<.001	3	10
URINARY_TRACT	APOL3 →	+2.538	+0.188	<.001	<.001	3	10
PANCREAS	PLAAT4 →	+3.374	+0.138	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	RTP4 →	+1.975	+0.116	.003	.003	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042088 vs PSMB9 — BREAST

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