T-helper 1 type immune response

Across TCGA cell cohorts, RNA activity of the T-helper 1 type immune response pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSNK1G2, LUC7L2, and DCXR, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T-helper 1 type immune response activity versus CSNK1G2 in OVARY (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CSNK1G2 →	+0.614	+0.405	<.001	<.001	3	7
SKIN	LUC7L2 →	+0.652	+0.392	.005	.007	3	6
STOMACH	DCXR →	+1.110	+0.346	.003	.008	3	5
BLOOD_Leukemia	PIMREG →	+1.654	+0.216	.009	<.001	3	5
LIVER	ATP6V1A →	+1.150	+0.366	.002	<.001	3	5
LIVER	ARHGAP29 →	-2.357	-0.448	.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042088 vs CSNK1G2 — OVARY

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