Cell migration involved in gastrulation

pathway activity — cross-omics
GO:0042074Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Cell migration involved in gastrulation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CIART, GOLM1, and SMIM11A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCCIART →+0.713+0.709.005<.00134
UCECGOLM1 →+0.771+0.497.006.00633
CCRCCSMIM11A →+0.021+0.460.004.00333
LUADLINC00609 →+1.214+0.578.003.00433
OVANAPC4 →+0.482+1.064.004<.00133
GBMFAM43B →+0.584+0.525<.001<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration