Cell migration involved in gastrulation

Across TCGA cell cohorts, RNA activity of the Cell migration involved in gastrulation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THEMIS2, EPHB4, and CREM, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, THEMIS2 grouped by Cell migration involved in gastrulation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	THEMIS2 →	-1.200	-1.101	.002	.001	3	4
BREAST	EPHB4 →	-0.922	-0.942	.002	.001	3	4
BLOOD_Myeloma	CREM →	+1.360	+0.395	<.001	.006	3	4
BLOOD_Lymphoma	EXT2 →	-2.530	-0.551	.006	<.001	2	4
BLOOD_Lymphoma	SH2B2 →	+2.790	+0.528	.005	.002	2	4
BLOOD_Lymphoma	NFATC2IP →	-0.685	-0.520	.002	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

THEMIS2 by Cell migration involved in gastrulation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →