Cell migration involved in gastrulation

Across TCGA cell cohorts, RNA activity of the Cell migration involved in gastrulation pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLCZ1, GOSR2, and PHF20L1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLCZ1 grouped by Cell migration involved in gastrulation-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PLCZ1 →	-0.258	-1.215	.003	.008	3	4
CNS	GOSR2 →	-0.119	-0.447	.008	.008	3	3
BLOOD_Leukemia	PHF20L1 →	-0.233	-1.228	<.001	<.001	3	3
BLOOD_Leukemia	VRK2 →	-0.223	-0.895	.007	.008	3	3
STOMACH	COTL1 →	-0.197	-1.606	.007	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	HUNK →	-0.164	-1.307	.008	.005	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLCZ1 by Cell migration involved in gastrulation activity — OESOPHAGUS

Explore this box plot interactively →