Intraciliary transport

Across TCGA patient cohorts, RNA activity of the Intraciliary transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BDH2, IFT140, and WDR54, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intraciliary transport activity versus BDH2 in BRCA (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	BDH2 →	+0.498	+0.047	<.001	<.001	3	9
BRCA	IFT140 →	+0.520	+0.057	<.001	<.001	3	9
UCEC	WDR54 →	+0.555	+0.085	<.001	<.001	3	8
BRCA	LZTFL1 →	+0.754	+0.054	<.001	<.001	3	8
BRCA	EPM2AIP1 →	+0.357	+0.042	<.001	<.001	3	8
BRCA	HDGFL3 →	+0.537	+0.036	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042073 vs BDH2 — BRCA

Explore this scatter interactively →