Intraciliary transport

Across TCGA patient cohorts, RNA activity of the Intraciliary transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RSPH1, DNAAF1, and ZMYND10, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intraciliary transport activity versus RSPH1 in BRCA (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RSPH1 →	+1.376	+0.873	<.001	<.001	3	7
BRCA	DNAAF1 →	+1.008	+0.770	<.001	<.001	3	6
BRCA	ZMYND10 →	+1.420	+0.778	<.001	<.001	3	6
BRCA	CFAP91 →	+0.768	+0.869	<.001	<.001	3	6
LSCC	RSPH4A →	+1.175	+0.913	<.001	.003	3	6
LSCC	CFAP94 →	+1.319	+1.068	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042073 vs RSPH1 — BRCA

Explore this scatter interactively →