Intraciliary transport

Across TCGA cell cohorts, RNA activity of the Intraciliary transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS6KA6, ZRANB2, and FCF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPS6KA6 grouped by Intraciliary transport-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	RPS6KA6 →	-2.480	-1.685	<.001	<.001	3	4
BLOOD_Myeloma	ZRANB2 →	-0.738	-1.689	.007	<.001	3	4
BLOOD_Leukemia	FCF1 →	+0.704	+1.133	.008	.001	3	4
PANCREAS	MESD →	+0.594	+1.355	<.001	<.001	3	4
PANCREAS	RAB27A →	+0.921	+1.196	.004	.002	3	4
KIDNEY	ZNF622 →	-0.828	-1.642	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPS6KA6 by Intraciliary transport activity — BLOOD_Lymphoma

Explore this box plot interactively →