Intraciliary transport

Across TCGA cell cohorts, RNA activity of the Intraciliary transport pathway is significantly associated with the shRNA dependency of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CR2, NUP43, and FCGBP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CR2 grouped by Intraciliary transport-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CR2 →	-0.163	-2.258	.001	.007	2	4
URINARY_TRACT	NUP43 →	+0.155	+1.770	.005	.004	3	3
BLOOD_Lymphoma	FCGBP →	+0.743	+1.820	.009	<.001	3	3
BLOOD_Lymphoma	CPS1 →	+0.296	+1.806	.003	<.001	3	3
BLOOD_Leukemia	RELT →	+0.178	+1.498	.004	<.001	2	4
SKIN	CST9L →	+0.111	+1.489	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CR2 by Intraciliary transport activity — URINARY_TRACT

Explore this box plot interactively →