Intraciliary transport

Across TCGA cell cohorts, RNA activity of the Intraciliary transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WASF2, ZSCAN20, and IQCH, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intraciliary transport activity versus WASF2 in LUNG_NSCLC_LUSC (Pearson r = 0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	WASF2 →	+1.057	+1.910	.003	<.001	3	4
SKIN	ZSCAN20 →	-0.493	-1.288	.001	.004	3	4
OVARY	IQCH →	-0.637	-1.026	<.001	.004	3	4
BLOOD_Lymphoma	MOSPD2 →	-1.056	-1.252	<.001	<.001	3	4
BLOOD_Lymphoma	TUBE1 →	-1.210	-0.967	.004	.003	3	4
LARGE_INTESTINE	ZBED1 →	-0.724	-0.979	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042073 vs WASF2 — LUNG_NSCLC_LUSC

Explore this scatter interactively →