Negative regulation of epidermal growth factor receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of epidermal growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHLDA2, S100A10, and EPGN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of epidermal growth factor receptor signaling pathway activity versus PHLDA2 in UCEC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PHLDA2 →	+0.744	+0.142	.009	.002	2	6
UCEC	S100A10 →	+0.685	+0.143	.002	<.001	3	5
HNSC	EPGN →	+1.880	+0.185	.001	.005	3	5
HNSC	KLRB1 →	-0.970	-0.237	<.001	<.001	3	4
UCEC	MET →	+1.260	+0.175	<.001	.002	3	4
LUAD	CISH →	+0.481	+0.114	.003	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042059 vs PHLDA2 — UCEC

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