Negative regulation of epidermal growth factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of epidermal growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA6, GGA2, and NABP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of epidermal growth factor receptor signaling pathway activity versus ITGA6 in LIVER (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ITGA6 →	+1.788	+0.350	.003	.002	3	4
BLOOD_Myeloma	GGA2 →	-0.796	-0.219	.007	.002	3	4
PANCREAS	NABP1 →	+2.027	+0.244	.002	.005	3	4
STOMACH	UEVLD →	+0.846	+0.186	.001	.005	3	4
LUNG_NSCLC_LUSC	ITGB1 →	+1.605	+0.400	.008	.004	2	5
LIVER	SSR1 →	-0.752	-0.247	.006	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042059 vs ITGA6 — LIVER

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