Epithelial fluid transport

Across TCGA patient cohorts, RNA activity of the Epithelial fluid transport pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H2AX, MXD3, and RNASEK, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epithelial fluid transport activity versus H2AX in COAD (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	H2AX →	-0.657	-0.391	.001	.004	3	3
GBM	MXD3 →	-0.595	-0.702	.003	.005	3	3
CCRCC	RNASEK →	+0.220	+0.547	.003	.003	3	3
PDAC	CATSPERB →	+1.001	+0.814	<.001	<.001	3	3
HNSC	ATP2B1-AS1 →	+0.275	+0.300	.005	.003	3	3
LUAD	POLR3A →	-0.294	-0.724	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042045 vs H2AX — COAD

Explore this scatter interactively →