Epithelial fluid transport

Across TCGA cell cohorts, RNA activity of the Epithelial fluid transport pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BNIP3, COPS9, and VMA21, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epithelial fluid transport activity versus BNIP3 in OESOPHAGUS (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	BNIP3 →	+2.347	+1.292	.006	.001	3	4
LUNG_NSCLC_LUSC	COPS9 →	-0.589	-1.394	.007	.008	2	5
OESOPHAGUS	VMA21 →	-0.651	-1.647	.005	<.001	3	3
OESOPHAGUS	AP1S2 →	-1.386	-1.453	.001	.005	3	3
LUNG_SCLC	ZNF595 →	+4.156	+2.018	<.001	<.001	3	3
BREAST	GSTP1 →	+7.625	+1.525	<.001	.009	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042045 vs BNIP3 — OESOPHAGUS

Explore this scatter interactively →