Protein refolding

Across TCGA patient cohorts, RNA activity of the Protein refolding pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UBTF, TNRC18_S1127, and ERO1A_S106, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein refolding activity versus UBTF in GBM (Pearson r = -0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	UBTF →	-0.297	-0.079	<.001	<.001	3	5
LUAD	TNRC18_S1127 →	-0.381	-0.050	.007	.004	2	6
LSCC	ERO1A_S106 →	+1.006	+0.058	<.001	<.001	2	6
GBM	IL4I1 →	+0.684	+0.093	<.001	<.001	3	5
LUAD	NAMPT_S472 →	+1.121	+0.042	.001	.004	3	5
OV	PLXND1 →	+0.212	+0.028	.009	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042026 vs UBTF — GBM

Explore this scatter interactively →