Protein refolding

Across TCGA patient cohorts, RNA activity of the Protein refolding pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FCRL2, ECM2, and PDE1A, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein refolding activity versus FCRL2 in COAD (Pearson r = 0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FCRL2 →	+0.385	+0.107	.004	.003	3	3
CCRCC	ECM2 →	+0.393	+0.084	.008	.006	3	3
CCRCC	PDE1A →	+1.005	+0.163	<.001	<.001	3	3
CCRCC	EHD3 →	+0.570	+0.146	.003	.001	3	3
CCRCC	FGF7 →	+0.926	+0.140	<.001	<.001	3	3
CCRCC	NPR2 →	+0.484	+0.173	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042026 vs FCRL2 — COAD

Explore this scatter interactively →