Protein refolding

Across TCGA cell cohorts, RNA activity of the Protein refolding pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSPB1, PLD4, and DOCK10, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein refolding activity versus HSPB1 in STOMACH (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	HSPB1 →	+3.003	+0.227	.004	<.001	3	8
BLOOD_Leukemia	PLD4 →	+2.502	+0.141	<.001	<.001	3	4
LUNG_SCLC	DOCK10 →	+1.479	+0.166	.002	.003	3	4
BLOOD_Leukemia	PREX1 →	+2.177	+0.146	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	MDH2 →	+0.614	+0.159	.002	.004	3	4
BLOOD_Leukemia	ZNF451 →	-0.690	-0.158	.008	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042026 vs HSPB1 — STOMACH

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