Polar body extrusion after meiotic divisions

Across TCGA patient cohorts, RNA activity of the Polar body extrusion after meiotic divisions pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFNL2, LPAR6, and NIFKP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Polar body extrusion after meiotic divisions activity versus IFNL2 in LSCC (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IFNL2 →	+0.132	+0.284	.001	.001	3	4
OV	LPAR6 →	-0.586	-0.651	.006	<.001	3	3
COAD	NIFKP1 →	+0.086	+0.333	.009	.005	3	3
LUAD	IGIP →	+0.312	+0.445	.006	.002	3	3
BRCA	RPL7AP14 →	+0.210	+0.443	.009	.004	3	3
GBM	SLCO4A1 →	-0.535	-0.440	.005	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0040038 vs IFNL2 — LSCC

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