Negative regulation of fibroblast growth factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of fibroblast growth factor receptor signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GATA3, SPRY2, and DDX4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GATA3 grouped by Negative regulation of fibroblast growth factor receptor signaling pathway-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GATA3 →	-0.625	-1.010	<.001	<.001	3	8
LIVER	SPRY2 →	-0.194	-1.155	.001	<.001	3	6
SKIN	DDX4 →	-0.176	-0.858	.002	<.001	3	5
CNS	PRDM14 →	-0.228	-0.891	<.001	<.001	3	5
URINARY_TRACT	CREB3L1 →	-0.250	-0.433	.005	.002	2	5
PANCREAS	STARD9 →	-0.204	-1.215	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GATA3 by Negative regulation of fibroblast growth factor receptor signaling pathway activity — BREAST

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